TRIM72 Mouse Monoclonal Antibody [A1D4] (EM1901-45)

UNIPROT #

Q6ZMU5

PROTEIN NAME

TRIM72

SYNONYMS

LOC493829 antibody;Mg53 antibody;Mitsugumin-53 antibody;TRI72_HUMAN antibody;trim72 antibody;Tripartite motif containing 72 antibody;Tripartite motif containing protein 72 antibody;Tripartite motif-containing protein 72 antibody

SEQUENCE SIMILARITIES

Belongs to the TRIM/RBCC family.

POST-TRANSLATIONAL MODIFICATION

Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.; S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.

SUBCELLULAR LOCATION

Sarcolemma, cytoplasmic vesicle membrane.

FUNCTION

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).