IGF1 (E peptide) Rabbit Polyclonal Antibody (HA500107)

UNIPROT #

P05019

PROTEIN NAME

IGF1 (E peptide)

SYNONYMS

IBP1 antibody;IGF I antibody;IGF IA antibody;IGF IB antibody;IGF-I antibody;Igf1 antibody;IGF1_HUMAN antibody;IGF1A antibody;IGFI antibody;IGFIA antibody;Insulin like growth factor 1 (somatomedin C) antibody;Insulin like growth factor 1 antibody;Insulin like growth factor IA antibody;Insulin like growth factor IB antibody;Insulin-like growth factor I antibody;Mechano growth factor antibody;MGF antibody;OTTHUMP00000195080 antibody;OTTHUMP00000195081 antibody;OTTHUMP00000195082 antibody;OTTHUMP00000195083 antibody;OTTHUMP00000195084 antibody;Somatomedia C antibody;Somatomedin C antibody;Somatomedin-C antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.