IGF2 Recombinant Rabbit Monoclonal Antibody [JJ092-3] (ET1701-88)

UNIPROT #

P01344

PROTEIN NAME

IGF2

SYNONYMS

C11orf43 antibody;IGF 2 antibody;IGF II antibody;IGF-II antibody;IGF2 antibody;IGF2_HUMAN antibody;IGFII antibody;INSIGF antibody;insulin like growth factor 2 (somatomedin A) antibody;Insulin like Growth Factor 2 antibody;Insulin like growth factor II antibody;Insulin like growth factor II precursor antibody;Insulin like growth factor type 2 antibody;pp9974 antibody;Preptin antibody;putative insulin like growth factor II associated protein antibody;Somatomedin A antibody;Somatomedin-A antibody

SEQUENCE SIMILARITIES

Belongs to the insulin family.

TISSUE SPECIFICITY

Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.

DEVELOPMENTAL STAGE

During embryogenesis, detected in liver, lung, skeletal muscle and placenta.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.; Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

IGF-II (Insulin-like growth factor II; also multiplication-stimulating polypeptide/MSP and somatomedin-A) is a secreted 8 kDa polypeptide that belongs to the insulin family of peptide growth factors. It is part of a complex system of growth and metabolic-regulating proteins that is particularly important during development. It has been associated with nervous system proliferation and differentiation, myelination, adrenal cortical proliferation, and skeletal growth and differentiation. In human, IGF-II is primarily synthesized by the liver, and circulates at high levels in both fetus and adult. In rodent, however, IGF-II levels drop after the perinatal period, an effect attributed to the lack of a key gene promoter. This may indicate that postnatally, IGF-II has either a limited, or local effect only in rodent.