Cytokeratin 5+6 Rabbit Polyclonal Antibody (ER1901-86)

UNIPROT #

P13647

PROTEIN NAME

Cytokeratin 5+6

SYNONYMS

58 kDa cytokeratin antibody;CK-5 antibody;CK5 antibody;Cytokeratin-5 antibody;Cytokeratin5 antibody;DDD antibody;DDD1 antibody;EBS2 antibody;epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types antibody;K2C5_HUMAN antibody;K5 antibody;keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) antibody;Keratin 5 antibody;Keratin antibody;keratin complex 2, basic, gene 5 antibody;keratin, type II cytoskeletal 5 antibody;Keratin-5 antibody;Keratin5 antibody;KRT 5 antibody;Krt5 antibody;KRT5A antibody;type II cytoskeletal 5 antibody;Type-II keratin Kb5 antibody;CK6 antibody;CK 6A antibody;CK 6B antibody;CK 6C antibody;CK 6D antibody;CK 6E antibody;CK-6B antibody;CK-6C antibody;CK-6E antibody;Cytokeratin 6a antibody;Cytokeratin 6B antibody;Cytokeratin 6C antibody;Cytokeratin 6D antibody;Cytokeratin 6E antibody;Cytokeratin-6B antibody;Cytokeratin-6C antibody;Cytokeratin-6E antibody;K2C6C_HUMAN antibody;K6a keratin antibody;K6b keratin antibody;K6C antibody;K6c keratin antibody;K6d keratin antibody;K6e keratin antibody;Keratin antibody;Keratin K6h antibody;Keratin type II cytoskeletal 6A antibody;Keratin type II cytoskeletal 6B antibody;Keratin type II cytoskeletal 6C antibody;Keratin type II cytoskeletal 6D antibody;Keratin type II cytoskeletal 6E antibody;Keratin-6C antibody;KRT6A antibody;KRT6B antibody;KRT6C antibody;KRT6D antibody;KRT6E antibody;type II cytoskeletal 6C antibody;Type-II keratin Kb12 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in corneal epithelium (at protein level).

SUBCELLULAR LOCATION

Cytoskeleton. Cytosol. Nucleus. Extracellular region or secreted.

FUNCTION

The protein encoded by this gene is a member of the keratin gene family. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Keratin 5 (and K14) are expressed primarily in basal keratinocytes in the epidermis, specifically in the stratified epithelium lining the skin and digestive tract. Keratin intermediate filaments make up the cytoskeletal scaffold within epithelial cells, which contributes to the cell architecture and provides the cells with the ability to withstand mechanical, and non-mechanical, stresses. K5/K14 keratin pairs are able to undergo extensive bundling due to the non-helical tail of K15 acting as a weak cross-linker at the intermediate filament surface. This bundling increases the elasticity, and therefore the mechanical resilience, of the intermediate filaments. K5/K14 intermediate filaments are anchored to the desmosomes of basal cells via desmoplakin and plakophilin-1, connecting the cells to their neighbours. At the hemidesmosome, plectin and BPAG1 associate with transmembrane proteins α6β4 integrin, a type of cell adhesion molecule, and BP180/collagen XVII, linking K5/K14 filaments in the basal cells to the basal lamina. Mutations of the cytokeratin 5 gene (KRT5) have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB).