Cytokeratin 9 Recombinant Rabbit Monoclonal Antibody [SD201-09] (ET1612-77)

UNIPROT #

P35527

PROTEIN NAME

Cytokeratin 9

SYNONYMS

CK 9 antibody;CK9 antibody;CK-9 antibody;Cytokeratin 9 antibody;Cytokeratin-9 antibody;Cytokeratin9 antibody;EPPK antibody;K1C9_HUMAN antibody;K9 antibody;Keratin 9 antibody;Keratin antibody;Keratin type I cytoskeletal 9 antibody;Keratin-9 antibody;Keratin9 antibody;KRT 9 antibody;Krt9 antibody;Spermatid Perinuclear Ring Manchette Protein K9 antibody;type I cytoskeletal 9 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in the terminally differentiated epidermis of palms and soles.

SUBCELLULAR LOCATION

Extracellular exosome, membrane, nucleus.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratin 9 is an unusually large, type I acidic cytokeratin that differentiates human plantar and palmar epidermal cells. Cytokeratin 9 localizes to the suprabasal layers as well as the upper epidermal layers such as the glandular ridges and interridges. The domains of cytokeratin 9 include a head, an α-helical coiled-coil-forming rod, and a tail; cytokeratin 9 shares significant homology with cytokeratin 10. Mutations in the cytokeratin 9 gene correlate with the development of epidermolytic palmoplantar keratoderma (EPPK), an autosomal dominant inherited skin disorder that is characterized by hyperkeratosis of the skin over the palms and soles.