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GATA4 Rabbit Polyclonal Antibody (R1107-5)

Price: Regular price $315.00

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Catalog# R1107-5

Rabbit Polyclonal to GATA4

Tested for

  • WB

  • FC

Reacts with

  • Human

  • Mouse

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

GATA4 Rabbit Polyclonal Antibody (R1107-5)

Immunogen

Synthetic peptide within human gata4 aa 280-430.

Host

Rabbit

Positive Control

HepG2, Jurkat, F9

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073184

APPLICATION DILUTION

  • WB

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 45 kDa

Isotype

IgG

TARGET

UNIPROT #

P43694

PROTEIN NAME

GATA4

SYNONYMS

ASD2 antibody;GATA 4 antibody;GATA binding protein 4 antibody;GATA-binding factor 4 antibody;gata4 antibody;GATA4_HUMAN antibody;MGC126629 antibody;Transcription factor GATA 4 antibody;Transcription factor GATA-4 antibody;Transcription factor GATA4 antibody;VSD1 antibody

POST-TRANSLATIONAL MODIFICATION

Methylation at Lys-300 attenuates transcriptional activity.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase.

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