CD34 Mouse Monoclonal Antibody [2-E9] (M1506-6)

UNIPROT #

P28906

PROTEIN NAME

CD34

SYNONYMS

CD34 antibody;CD34 antigen antibody;CD34 molecule antibody;CD34_HUMAN antibody;Cluster designation 34 antibody;Hematopoietic progenitor cell antigen CD34 antibody;HPCA1 antibody;Mucosialin antibody;OTTHUMP00000034733 antibody;OTTHUMP00000034734 antibody

SEQUENCE SIMILARITIES

Belongs to the CD34 family.

TISSUE SPECIFICITY

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

DEVELOPMENTAL STAGE

On early hematopoietic progenitor cells.

POST-TRANSLATIONAL MODIFICATION

Highly glycosylated.; Phosphorylated on serine residues by PKC.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD34 is a heavily glycosylated type I transmembrane molecule, that can be phoshorylated by a variety of kinases including Protein kinase C and Tyrosine kinases. CD34 antigen is expressed on small vessel endothelial cells and tumors of epithelial origin. CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. So CD34 is considered to be ideal marker for identifying and quantifying hematopoietic progenitor stem cells. With interaction with CrkL, CD34 becomes a substrate for PKC and CD34 surface expression is associated with activation of PKC.