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Noggin Rabbit Polyclonal Antibody (ER1802-30)

Price: Regular price $315.00

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Catalog# ER1802-30

Rabbit Polyclonal to Noggin

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

Noggin Rabbit Polyclonal Antibody (ER1802-30)

Immunogen

Recombinant full length protein of human noggin.

Host

Rabbit

Positive Control

Noggin Recombinant protein, PC-3M, human placenta tissue, human liver tissue, mouse liver tissue, rat liver tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069129

APPLICATION DILUTION

  • WB

  • 1:500

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 26 kDa

Isotype

IgG

TARGET

UNIPROT #

Q13253

PROTEIN NAME

Noggin

SYNONYMS

Nog antibody;NOGG_HUMAN antibody;Noggin antibody;SYM 1 antibody;SYM1 antibody;Symphalangism 1 (proximal) antibody;Synostoses (multiple) syndrome 1 antibody;SYNS 1 antibody;SYNS1 antibody

SEQUENCE SIMILARITIES

Belongs to the noggin family.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Genetic differentiation of the vertebrate somite necessitates a balance of inductive signals and antagonists. Noggin is a secreted protein that binds and inactivates members of the transforming growth factor-beta (TGFβ) superfamily of signaling proteins, such as bone morphogenetic proteins-2, 4, 7 (BMP2, BMP4, BMP7). Inhibition of BMP signaling by axially secreted Noggin mediates normal vertebrate skeletogenesis and patterning of the neural tube and somite. Spatially, Noggin may effectively antagonize BMP activity by efficiently diffusing through extracellular matrices, thereby creating morpho-genic gradients. Mice embryos that are homozygous null for Noggin, a lethal genotype, display stubby, continuous limbs with lack of joints in the paws and an array of other developmental defects.

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