SFRP1 Rabbit Polyclonal Antibody (ER1802-34)

UNIPROT #

Q8N474

PROTEIN NAME

SFRP1

SYNONYMS

Frizzled related protein 1 antibody;FRP 1 antibody;FRP antibody;FRP-1 antibody;FRP1 antibody;FrzA antibody;SARP 2 antibody;SARP-2 antibody;SARP2 antibody;Secreted apoptosis related protein 2 antibody;Secreted apoptosis-related protein 2 antibody;Secreted frizzled related protein 1 antibody;Secreted frizzled related protein antibody;Secreted frizzled-related protein 1 antibody;SFRP 1 antibody;sFRP-1 antibody;SFRP1 antibody;SFRP1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the secreted frizzled-related protein (sFRP) family.

TISSUE SPECIFICITY

Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.