IGF1R Mouse Monoclonal Antibody [D5-G2] (HA600033)

UNIPROT #

P08069

PROTEIN NAME

IGF1R

SYNONYMS

Insulin-like growth factor 1 receptor beta chain antibody;CD221 antibody;CD221 antigen antibody;IGF 1 receptor antibody;IGF 1R antibody;IGF I receptor antibody;IGF-I receptor antibody;Igf1r antibody;IGF1R_HUMAN antibody;IGFIR antibody;IGFIRC antibody;IGFR antibody;Insulin like growth factor 1 receptor antibody;Insulin like growth factor 1 receptor precursor antibody;Insulin-like growth factor 1 receptor beta chain antibody;Insulin-like growth factor I receptor antibody;JTK13 antibody;MGC142170 antibody;MGC142172 antibody;MGC18216 antibody;Soluble IGF1R variant 1 antibody;Soluble IGF1R variant 2 antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane.

FUNCTION

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.