ESRRB Rabbit Polyclonal Antibody (R1308-2)

UNIPROT #

O95718

PROTEIN NAME

ESRRB

SYNONYMS

Err 2 antibody;ERR b antibody;ERR B2 antibody;ERR beta 2 antibody;ERR beta antibody;ERR beta-2 antibody;ERR-beta antibody;Err2 antibody;ERR2_HUMAN antibody;ERRB 2 antibody;ERRb antibody;ERRB2 antibody;ERRbeta 2 antibody;ERRbeta antibody;ESR L2 antibody;ESRL 2 antibody;ESRL2 antibody;Esrrb antibody;Estrogen receptor like 2 antibody;Estrogen receptor related 2 antibody;Estrogen receptor-like 2 antibody;Estrogen-related receptor beta antibody;Estrrb antibody;Nr3b2 antibody;Nuclear receptor ERRB2 antibody;Nuclear receptor subfamily 3 group B member 2 antibody;Orphan nuclear receptor antibody;Steroid hormone receptor ERR 2 antibody;Steroid hormone receptor ERR2 antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR3 subfamily.

POST-TRANSLATIONAL MODIFICATION

Acetylated by PCAF/KAT2 (in vitro).

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Chromosome.

FUNCTION

Steroid hormone receptors are found on the plasma membrane, in the cytosol and also in the nucleus of target cells. They are generally intracellular receptors and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days. Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35). DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.