Androgen Receptor Rabbit Polyclonal Antibody (ER2001-34)

UNIPROT #

P10275

PROTEIN NAME

Androgen Receptor

SYNONYMS

AIS antibody;ANDR_HUMAN antibody;Androgen nuclear receptor variant 2 antibody;Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) antibody;Androgen receptor antibody;androgen receptor splice variant 4b antibody;AR antibody;AR8 antibody;DHTR antibody;Dihydro testosterone receptor antibody;Dihydrotestosterone receptor (DHTR) antibody;Dihydrotestosterone receptor antibody;HUMARA antibody;HYSP1 antibody;KD antibody;Kennedy disease (KD) antibody;NR3C4 antibody;Nuclear receptor subfamily 3 group C member 4 (NR3C4) antibody;Nuclear receptor subfamily 3 group C member 4 antibody;SBMA antibody;SMAX1 antibody;Spinal and bulbar muscular atrophy (SBMA) antibody;Spinal and bulbar muscular atrophy antibody;Testicular Feminization (TFM) antibody;TFM antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus

FUNCTION

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation . Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.9 Publications Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.