KAT4/TAF1 Rabbit Polyclonal Antibody (HA500183)

UNIPROT #

P21675

PROTEIN NAME

KAT4/TAF1

SYNONYMS

BA2R antibody;CCG 1 antibody;CCG1 antibody;CCGS antibody;Cell cycle G1 phase defect antibody;Cell cycle gene 1 protein antibody;Complementation of cell cycle block G1 to S antibody;DYT3 protein antibody;NSCL 2 antibody;NSCL2 antibody;OF antibody;p250 antibody;TAF 1 antibody;TAF(II)250 antibody;TAF1 RNA polymerase II antibody;TAF130 antibody;TAF145 antibody;TAF2A antibody;TAFII 250 antibody;TAFII250 antibody;TATA box binding protein (TBP) associated factor RNA polymerase II A 250kD antibody;TATA box binding protein (TBP)-associated factor antibody;TBP associated factor 1 antibody;TBP associated factor 145 kDa antibody;TBP associated factor 250 kDa antibody;Transcription factor TFIID p250 polypeptide antibody;Transcription initiation factor TFIID 250 kDa subunit antibody;Transcription initiation factor TFIID subunit 1 antibody;YGR274C antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons.