CDKN1A/P21 Rabbit Polyclonal Antibody (HA500156)

UNIPROT #

P38936

PROTEIN NAME

CDKN1A/P21

SYNONYMS

CAP20 antibody;CDK-interacting protein 1 antibody;CDKI antibody;CDKN1 antibody;Cdkn1a antibody;CDN1A_HUMAN antibody;CIP1 antibody;Cyclin Dependent Kinase Inhibitor 1A antibody;Cyclin-dependent kinase inhibitor 1 antibody;Cyclin-dependent kinase inhibitor 1A (P21) antibody;Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody;DNA Synthesis Inhibitor antibody;MDA-6 antibody;MDA6 antibody;Melanoma differentiation-associated protein 6 antibody;Melanoma differentiation-associated protein antibody;p21 antibody;P21 protein antibody;p21CIP1 antibody;p21Cip1/Waf1 antibody;p21WAF antibody;PIC1 antibody;SDI1 antibody;SLC12A9 antibody;WAF1 antibody;Wild type p53 activated fragment 1 (WAF1) antibody;Wild type p53 activated fragment 1 antibody;Wildtype p53-activated fragment 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and thus functions as a regulator of cell cycle progression at G1 and S phase. p21 interacts with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. However p21 may inhibit apoptosis and does not induce cell death on its own. The ability of p21 to inhibit apoptosis in response to replication fork stress has also been reported. Studies of p53 dependent cell cycle arrest in response to DNA damage identified p21 as the primary mediator of downstream cell cycle arrest. p21 is negatively regulated by ubiquitin ligases both over the course of the cell cycle and in response to DNA damage. Cytoplasmic p21 expression can be significantly correlated with lymph node metastasis, distant metastases, advanced TNM stage, depth of invasion and OS.