Ras Recombinant Rabbit Monoclonal Antibody [SA39-05] (ET1601-16)

UNIPROT #

P01111

PROTEIN NAME

Ras

SYNONYMS

C-BAS/HAS antibody;c-H-ras antibody;C-HA-RAS1 antibody;CTLO antibody;GTPase HRas antibody;GTPase KRas antibody;GTPase NRas antibody;H-Ras-1 antibody;H-RASIDX antibody;Ha-Ras antibody;HAMSV antibody;HRAS antibody;HRAS1 antibody;K RAS2A antibody;K RAS2B antibody;K RAS4A antibody;K RAS4B antibody;K-RAS antibody;KRAS antibody;KRAS1 antibody;KRAS2 antibody;N-RAS antibody;N-terminally processed antibody;NRAS antibody;NRAS1 antibody;p21ras antibody;RASH_HUMAN antibody;RASH1 antibody;RASK2 antibody;Transforming protein p21 antibody;v Ha ras Harvey rat sarcoma viral oncogene homolog antibody;v Ki ras2 Kirsten rat sarcoma viral oncogene homolog antibody;v ras neuroblastoma RAS viral oncogene homolog antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. Ras family.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.; Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).; Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.; Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane, Golgi apparatus.

FUNCTION

Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in three-dimensional structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation, and survival. Mutations in Ras genes can lead to the production of permanently activated Ras proteins, which can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The three Ras genes in humans (HRAS, KRAS, and NRAS) are the most common oncogenes in human cancer.