CDK6 Rabbit Polyclonal Antibody (ER40101)

UNIPROT #

Q00534

PROTEIN NAME

CDK6

SYNONYMS

CDK 6 antibody;CDK6 antibody;CDK6_HUMAN antibody;Cell division protein kinase 6 antibody;Crk 2 antibody;Crk2 antibody;Cyclin dependent kinase 6 antibody;Cyclin-dependent kinase 6 antibody;MGC59692 antibody;p40 antibody;PLSTIRE antibody;Serine/threonine protein kinase PLSTIRE antibody;Serine/threonine-protein kinase PLSTIRE antibody;STQTL11 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

TISSUE SPECIFICITY

Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.

POST-TRANSLATIONAL MODIFICATION

Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.

SUBCELLULAR LOCATION

Cytoplasm, nucleus, Cell projection, Cytoskeleton.

FUNCTION

CDK6 protein contains a catalytic core composed of a serine/threonine domain.This protein also contains an ATP-binding pocket, inhibitory and activating phosphorylation sites, a PSTAIRE-like cyclin-binding domain and an activating T-loop motif. CDK6 is involved in a positive feedback loop that activates transcription factors through a reaction cascade. CDK6 is important for the control of G1 to S phase transition. However, in recent years, new evidence proved that the presence of CDK6 is not essential for proliferation in every cell type, the cell cycle has a complex circuitry of regulation and the role of CDK6 might be more important in certain cell types than in others, where CDK4 or CDK2 can act as protein kinases compensating its role.