Ferritin Light Chain Recombinant Rabbit Monoclonal Antibody [JM10-37] (ET1705-54)

UNIPROT #

P02792

PROTEIN NAME

Ferritin Light Chain

SYNONYMS

Ferritin L chain antibody;Ferritin L subunit antibody;Ferritin light chain antibody;Ferritin light polypeptide antibody;ferritin light polypeptide like 3 antibody;FRIL_HUMAN antibody;FTL antibody;LFTD antibody;NBIA 3 antibody;NBIA3 antibody

SEQUENCE SIMILARITIES

Belongs to the ferritin family.

SUBCELLULAR LOCATION

Cytosol, extracellular exosome, extracellular region, autolysosome, azurophil granule lumen, cytoplasm, intracellular ferritin complex, membrane.

FUNCTION

Mammalian ferritins consist of 24 subunits made up of two types of polypeptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts. The gene encoding human ferritin heavy chain maps to chromosome 11q13 and the human ferritin light chain gene maps to chromosome 19q13.3-q13.4.