Podoplanin Recombinant Rabbit Monoclonal Antibody [JM31-21] (ET1703-61)

UNIPROT #

Q86YL7

PROTEIN NAME

Podoplanin

SYNONYMS

Aggrus antibody;Glycoprotein 36 KD antibody;Glycoprotein 36 antibody;gp 36 antibody;GP 38 antibody;GP 40 antibody;gp36 antibody;GP38 antibody;GP40 antibody;HT1A 1 antibody;HT1A1 antibody;hT1alpha 1 antibody;hT1alpha 2 antibody;hT1alpha1 antibody;hT1alpha2 antibody;Lung type I cell membrane associated glycoprotein antibody;Lung type I cell membrane associated glycoprotein isoform a antibody;Lung type I cell membrane associated glycoprotein T1A 2 antibody;OTS 8 antibody;OTS8 antibody;OTTHUMP00000009640 antibody;OTTHUMP00000044504 antibody;PA2.26 antibody;PA2.26 antigen antibody;Pdpn antibody;PDPN_HUMAN antibody;Podoplanin antibody;PSEC0003 antibody;PSEC0025 antibody;T1 alpha antibody;T1 ALPHA GENE antibody;T1-alpha antibody;T1A 2 antibody;T1A antibody;TI1A antibody;TIA 2 antibody;TIA2 antibody

SEQUENCE SIMILARITIES

Belongs to the podoplanin family.

TISSUE SPECIFICITY

Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.

POST-TRANSLATIONAL MODIFICATION

Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. Disialylated at Thr-52; sialic acid is critical for platelet-aggregating activity and for CLEC1B interaction.; The N-terminus is blocked.; Cleaved by a metalloprotease within its extracellular (EC) domain, generating a membrane-bound C-terminal fragment (PCTF33) and an extracellular fragment. The resulting membrane-bound C-terminal fragment (PCTF33) is further processed between Val-150 and Val-151 by PSEN1/gamma-secretase generating the intracellular domain of podoplanin (PICD).

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane.

FUNCTION

Puromycin aminonucleoside nephrosis (PAN) is a rat model for human minimal change nephropathy. During PAN, severe proteinuria is induced that is paralleled by a reduced expression of a rat podocyte protein, named podoplanin. Podoplanin, also known as glycoprotein 38 (gp38) is a type I membrane protein. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes.