IMP3 Mouse Monoclonal Antibody [4-C2-5] (EM1801-01)

UNIPROT #

O00425

PROTEIN NAME

IMP3

SYNONYMS

Cancer/testis antigen 98 antibody;CT98 antibody;DKFZp686F1078 antibody;hKOC antibody;IF2B3_HUMAN antibody;IGF II mRNA binding protein 3 antibody;IGF-II mRNA-binding protein 3 antibody;IGF2 mRNA binding protein 3 antibody;IGF2 mRNA-binding protein 3 antibody;IGF2BP3 antibody;IMP 3 antibody;IMP-3 antibody;Insulin like growth factor 2 mRNA binding protein 3 antibody;Insulin-like growth factor 2 mRNA-binding protein 3 antibody;KH domain containing protein overexpressed in cancer antibody;KH domain-containing protein overexpressed in cancer antibody;KOC 1 antibody;KOC1 antibody;VICKZ 3 antibody;VICKZ family member 3 antibody;VICKZ3 antibody

SEQUENCE SIMILARITIES

Belongs to the RRM IMP/VICKZ family.

TISSUE SPECIFICITY

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.