UHRF1 Recombinant Rabbit Monoclonal Antibody [PSH10-63] (HA723228)

UNIPROT #

Q96T88

PROTEIN NAME

UHRF1

SYNONYMS

Ac2-121 antibody;AL022808 antibody;E3 ubiquitin-protein ligase UHRF1 antibody;EC 6.3.2.- antibody;FLJ21925 antibody;hNP95 antibody;hUHRF1 antibody;HuNp95 antibody;ICBP90 antibody;Inverted CCAAT box binding protein of 90 kDa antibody;Inverted CCAAT box binding protein, 90-kD antibody;Inverted CCAAT box-binding protein of 90 kDa antibody;Liver regeneration-related protein LRRG126 antibody;MGC138707 antibody;NP95 antibody;Nuclear phosphoprotein 95 antibody;Nuclear phosphoprotein, 95-KD antibody;Nuclear protein 95 antibody;Nuclear zinc finger protein Np95 antibody;RING finger protein 106 antibody;RNF106 antibody;TDRD22 antibody;Transcription factor ICBP90 antibody;Ubiquitin like containing PHD and RING finger domains protein 1 antibody;Ubiquitin like PHD and RING finger domain containing protein 1 antibody;Ubiquitin-like PHD and RING finger domain-containing protein 1 antibody;Ubiquitin-like protein containing PHD and RING finger domains 1 antibody;Ubiquitin-like with PHD and ring finger domains 1 antibody;Ubiquitin-like, containing PHD and RING finger domains, 1 antibody;Ubiquitin-like-containing PHD and RING finger domains protein 1 antibody;UHRF1 antibody;UHRF1_HUMAN antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to hemi-methylated DNA during S-phase and recruits the main DNA methyltransferase protein, DNMT1, to regulate chromatin structure and gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.