Elp3 Recombinant Rabbit Monoclonal Antibody [JE60-10] (HA720046)

UNIPROT #

Q9H9T3

PROTEIN NAME

Elp3

SYNONYMS

DKFZp761L098 antibody;Elongation protein 3 homolog (S. cerevisiae) antibody;Elongation protein 3 homolog antibody;ELONGATION PROTEIN 3, S. CEREVISIAE, HOMOLOG OF antibody;elongator acetyltransferase complex subunit 3 antibody;Elongator complex protein 3 antibody;elp3 antibody;ELP3_HUMAN antibody;FLJ10422 antibody;hELP3 antibody;Hypothetical protein DKFZp761L098 antibody;Kat9 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex (By similarity).