PRMT5 Recombinant Rabbit Monoclonal Antibody [ST51-06] (ET1609-43)

UNIPROT #

O14744

PROTEIN NAME

PRMT5

SYNONYMS

72 kDa ICln binding protein antibody;72 kDa ICln-binding protein antibody;ANM5_HUMAN antibody;Histone synthetic lethal 7, S. cerevisiae, homolog of antibody;Histone-arginine N-methyltransferase PRMT5 antibody;HMT1 hnRNP methyltransferase like 5 antibody;HOMOLOG OF; SKB1 antibody;HRMT1L5 antibody;IBP72 antibody;Jak-binding protein 1 antibody;JBP 1 antibody;JBP1 antibody;PRMT 5 antibody;PRMT5 antibody;Protein arginine methyltransferase 5 antibody;Protein arginine N methyltransferase 5 antibody;Protein arginine N methyltransferase 5 N terminally processed antibody;Protein arginine N-methyltransferase 5 antibody;S. POMBE antibody;S. POMBE HOMOLOG OF; SKB1 antibody;SHK1 KINASE BINDING PROTEIN 1 antibody;Shk1 kinase binding protein 1 homolog antibody;Shk1 kinase-binding protein 1 homolog antibody;Shk1 kinase/binding protein 1, S. pombe, homolog of antibody;SKB 1 antibody;SKB1 antibody;SKB1 homolog antibody;SKB1: SKB1 homolog (S. pombe) antibody;SKB1Hs antibody

SEQUENCE SIMILARITIES

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.

TISSUE SPECIFICITY

Ubiquitous.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Golgi apparatus, Chromosome.

FUNCTION

The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of a motor neuron (SMN) protein and is enhanced by modification of specific Arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5, also designated JAK-binding protein 1), (JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their Arginine- and Glycine-rich (RG) domains, while pICln binds the Sm domains. PRMT5 is a distinct member of the protein-Arginine methyltransferase (PRMT) family, and predominantly localizes to the cytoplasm in a wide variety of tissues. PRMT5 also associates specifically with the transcription start site region of the cyclin E1 promoter, and, therefore, is involved in the control of transcription and proliferation. The gene encoding human PRMT5 maps to chromosome 14q11.