CAMKIV Recombinant Rabbit Monoclonal Antibody [JB33-13] (ET7107-96)

UNIPROT #

Q16566

PROTEIN NAME

CAMKIV

SYNONYMS

Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody;Brain Ca(2+) calmodulin dependent protein kinase type IV antibody;Brain Ca++-calmodulin dependent protein kinase type IV antibody;Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody;Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody;Calcium/calmodulin dependent protein kinase IV antibody;Calcium/calmodulin dependent protein kinase type IV antibody;Calcium/calmodulin-dependent protein kinase type IV antibody;CAM kinase 4 antibody;CAM kinase GR antibody;CAM kinase IV antibody;CAM kinase-GR antibody;CaMK 4 antibody;CAMK GR antibody;CaMK IV antibody;Camk4 antibody;CaMKGR antibody;IV antibody;KCC4_HUMAN antibody;MGC36771 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

TISSUE SPECIFICITY

Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.

DEVELOPMENTAL STAGE

Expressed during differentiation of monocyte-derived dendritic cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.; Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.