Cdc34 Recombinant Rabbit Monoclonal Antibody [JJ086-07] (ET1701-10)

UNIPROT #

P49427

PROTEIN NAME

Cdc34

SYNONYMS

Cdc 34 antibody;Cdc34 antibody;Cell division cycle 34 antibody;Cell division cycle 34 homolog (S. cerevisiae) antibody;Cell division cycle 34 homolog antibody;E2 CDC34 antibody;UB2R1_HUMAN antibody;UBC 3 antibody;UBC3 antibody;UBCH3 antibody;UBE2 R1 antibody;UBE2R1 antibody;Ubiquitin carrier protein antibody;Ubiquitin conjugating enzyme Cdc34 antibody;Ubiquitin conjugating enzyme E2 32 kDa complementing antibody;Ubiquitin protein ligase antibody;Ubiquitin protein ligase R1 antibody;Ubiquitin-conjugating enzyme E2 R1 antibody;Ubiquitin-conjugating enzyme E2-32 kDa complementing antibody;Ubiquitin-conjugating enzyme E2-CDC34 antibody;Ubiquitin-protein ligase R1 antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin-conjugating enzyme family.

TISSUE SPECIFICITY

Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription.

POST-TRANSLATIONAL MODIFICATION

Autoubiquitinated. Autoubiquitination is promoted by the human herpes virus 1 protein ICP0 and leads to degradation by the Ubiquitin-proteasomal pathway.; Phosphorylated by CK2. Phosphorylation of the C-terminal tail by CK2 controles the nuclear localization.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins. CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle. Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1 for ubiquitin-mediated protein degradation. CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.