USP36 Rabbit Polyclonal Antibody (ER1706-23)

UNIPROT #

Q9P275

PROTEIN NAME

USP36

SYNONYMS

Deubiquitinating enzyme 1 antibody;Deubiquitinating enzyme 36 antibody;DUB1 antibody;FLJ12851 antibody;KIAA1453 antibody;Ubiquitin carboxyl-terminal hydrolase 36 antibody;Ubiquitin specific peptidase 36 antibody;Ubiquitin specific processing protease 36 antibody;Ubiquitin thioesterase 36 antibody;Ubiquitin thiolesterase 36 antibody;Ubiquitin-specific-processing protease 36 antibody;UBP36_HUMAN antibody;Usp36 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C19 family.

TISSUE SPECIFICITY

Broadly expressed.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated by NEDD4L, no effect on USP36 protein levels. Both proteins interact with and regulate each other's ubiquitination levels.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubuquitinate nucleophosmin and fibrillarin. May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4).