p150 CAF1 Recombinant Rabbit Monoclonal Antibody [JG38-98] (ET7108-83)

UNIPROT #

Q13111

PROTEIN NAME

p150 CAF1

SYNONYMS

CAF 1 antibody;CAF 1 subunit A antibody;CAF antibody;CAF I 150 kDa subunit antibody;CAF I p150 antibody;CAF-1 subunit A antibody;CAF-I 150 kDa subunit antibody;CAF-I p150 antibody;CAF1 antibody;CAF1A_HUMAN antibody;CAF1B antibody;CAF1P150 antibody;CHAF1A antibody;Chromatin assembly factor 1 subunit A antibody;Chromatin Assembly Factor 1 Subunit A p150 antibody;Chromatin assembly factor I (150 kDa) antibody;Chromatin assembly factor I 150 kDa antibody;Chromatin assembly factor I p150 subunit antibody;DCAF1 antibody;hp150 antibody;MGC71229 antibody;P150 antibody

SEQUENCE SIMILARITIES

Belongs to the CHAF1A family.

DEVELOPMENTAL STAGE

Active complex is found in G1, S and G2 phases.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Chromatin assembly factor-1 (CAF-1) is a multisubunit protein complex that comprises three polypeptide subunits known as p150, p60, and p48. CAF-1 is a nucleosome assembly factor that deposits newly synthesized and acetylated Histones H3/H4 into nascent chromatin during DNA replication. The p150 subunit of CAF-1 also supports the maintenance of heterochromatin, which requires the synthesis of both new histones and heterochromatin proteins and their orderly assembly during DNA replication. Heterochromatin is characterized as densely coiled chromatin that generally replicates late during S phase, has a low gene density, and contains large blocks of repetitive DNA that is relatively inaccessible to DNA-modifying reagents. In late S phase, p150 directly associates with heterochromatin associated proteins 1 (HP1α, HP1β and HP1γ). As cells prepare for mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin, coinciding with the phosphorylation of histone H3. The HP1 proteins reassociate with chromatin at the end of mitosis, as histone H3 is dephosphorylated.