RbAP48 Recombinant Rabbit Monoclonal Antibody [JU37-47] (ET1706-54)

UNIPROT #

Q09028

PROTEIN NAME

RbAP48

SYNONYMS

CAF I p48 antibody;CAF-1 subunit C antibody;CAF-I 48 kDa subunit antibody;CAF-I p48 antibody;Chromatin assembly factor 1 subunit C antibody;Chromatin assembly factor I p48 subunit antibody;Chromatin assembly factor/CAF 1 p48 subunit antibody;Histone-binding protein RBBP4 antibody;MSI1 protein homolog antibody;Nucleosome-remodeling factor subunit RBAP48 antibody;NURF55 antibody;RB binding protein 4 chromatin remodeling factor antibody;RbAp 48 antibody;RBAP48 antibody;RBBP-4 antibody;RBBP4 antibody;RBBP4_HUMAN antibody;Retinoblastoma binding protein 4 antibody;Retinoblastoma binding protein p48 antibody;Retinoblastoma-binding protein 4 antibody;Retinoblastoma-binding protein p48 antibody

SEQUENCE SIMILARITIES

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

In the intact cell, DNA is closely associated with histones and other nuclear proteins to form chromatin.The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation, and an increased accessiblity of DNA to transcription factors. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases. The retinoblastoma binding proteins RbAp46 and RbAp48 have been identified as histone binding proteins, and they are components of the histone deacetylase complex.