MTA2 Mouse Monoclonal Antibody [17A2] (EM1901-74)

UNIPROT #

O94776

PROTEIN NAME

MTA2

SYNONYMS

DKFZp686F2281 antibody;Mata1l1 antibody;Metastasis associated 1 family member 2 antibody;Metastasis associated 1 like 1 antibody;Metastasis associated gene 1 like 1 antibody;Metastasis associated gene family member 2 antibody;Metastasis associated protein 2 antibody;Metastasis associated protein MTA 2 antibody;Metastasis associated protein MTA2 antibody;Metastasis-associated 1-like 1 antibody;Metastasis-associated protein MTA2 antibody;Mmta2 antibody;MTA1 L1 protein antibody;MTA1-L1 protein antibody;MTA1L1 antibody;MTA2 antibody;MTA2_HUMAN antibody;p53 target protein in deacetylase complex antibody;PID antibody

TISSUE SPECIFICITY

Widely expressed.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.