CHD4 Recombinant Rabbit Monoclonal Antibody [JA33-40] (ET1704-53)

UNIPROT #

Q14839

PROTEIN NAME

CHD4

SYNONYMS

ATP dependent helicase CHD4 antibody;ATP-dependent helicase CHD4 antibody;CHD 4 antibody;CHD-4 antibody;CHD4 antibody;CHD4_HUMAN antibody;Chromodomain helicase DNA binding protein 4 antibody;Chromodomain-helicase-DNA-binding protein 4 antibody;Mi 2 autoantigen 218 kDa protein antibody;Mi 2b antibody;Mi-2 autoantigen 218 kDa protein antibody;Mi2 beta antibody;Mi2-beta antibody

SEQUENCE SIMILARITIES

Belongs to the SNF2/RAD54 helicase family.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Chromatin structure alteration may be brought about by the action of ATP-dependent multiprotein complexes. One such complex is the mSin3 corepressor complex, which contains mSin3, the histone deacetylases HDAC1 and HDAC2, the associated proteins SAP 30 and SAP 18, and the autoantigens Mi2-α and Mi2-β.