RBBP7 Rabbit Polyclonal Antibody (HA500155)

UNIPROT #

Q16576

PROTEIN NAME

RBBP7

SYNONYMS

G1/S transition control protein binding protein RbAp46 antibody;Histone acetyltransferase type B subunit 2 antibody;Histone binding protein RBBP7 antibody;Histone-binding protein RBBP7 antibody;MGC138867 antibody;MGC138868 antibody;Nucleosome remodeling factor subunit RBAP46 antibody;Nucleosome-remodeling factor subunit RBAP46 antibody;RBAP46 antibody;RBBP 7 antibody;RBBP-7 antibody;RBBP7 antibody;RBBP7_HUMAN antibody;Retinoblastoma binding protein 7 antibody;Retinoblastoma binding protein p46 antibody;Retinoblastoma-binding protein 7 antibody;Retinoblastoma-binding protein p46 antibody;Retinoblastoma-binding protein RbAp46 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.