BRG1 Rabbit Polyclonal Antibody (HA500262)

UNIPROT #

P51532

PROTEIN NAME

BRG1

SYNONYMS

ATP dependent helicase SMARCA4 antibody;ATP-dependent helicase SMARCA4 antibody;BAF 190 antibody;BAF190 antibody;BAF190A antibody;Brahma protein like 1 antibody;BRG1 antibody;BRG1 associated factor 190A antibody;BRG1 protein antibody;BRG1-associated factor 190A antibody;BRM/SWI2 related gene 1 antibody;Global transcription activator homologous sequence antibody;global transcription activator snf2l4 antibody;Homeotic gene regulator antibody;hSNF2b antibody;Mitotic growth and transcription activator antibody;MRD16 antibody;Nuclear protein GRB1 antibody;Protein brahma homolog 1 antibody;Protein BRG-1 antibody;Protein BRG1 antibody;RTPS2 antibody;SMARC A4 antibody;SMARCA4 antibody;SMCA4_HUMAN antibody;SNF2 antibody;SNF2 beta antibody;SNF2 like 4 antibody;SNF2-beta antibody;SNF2B antibody;SNF2L4 antibody;SNF2LB antibody;Sucrose nonfermenting like 4 antibody;SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4 antibody;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 antibody;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 antibody;SWI2 antibody;Transcription activator BRG1 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP.