SMARCC1 Recombinant Rabbit Monoclonal Antibody [JB43-43] (ET7107-12)

UNIPROT #

Q92922

PROTEIN NAME

SMARCC1

SYNONYMS

AI115498 antibody;BAF 155 antibody;BAF155 antibody;BRG 1 associated factor 155 antibody;BRG1 associated factor 155 antibody;BRG1-associated factor 155 antibody;Chromatin remodeling complex BAF155 subunit antibody;CRACC 1 antibody;CRACC1 antibody;Mammalian chromatin remodeling complex BRG 1 associated factor 155 antibody;Mammalian chromatin remodeling complex BRG1 associated factor 155 antibody;Rsc 8 antibody;Rsc8 antibody;SMARC C1 antibody;SMARCC 1 antibody;SMARCC1 antibody;SMRC1_HUMAN antibody;SRG 3 antibody;SRG3 antibody;SWI 3 antibody;SWI/SNF complex 155 kDa subunit antibody;SWI/SNF complex subunit SMARCC1 antibody;SWI/SNF related matrix associated actin dependent regulator of chromatin c1 antibody;SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1 antibody;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 antibody;SWI3 antibody

SEQUENCE SIMILARITIES

Belongs to the SMARCC family.

TISSUE SPECIFICITY

Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SWI/SNF and contains a predicted leucine zipper motif typical of many transcription factors. Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.