KIFAP3 Recombinant Rabbit Monoclonal Antibody [JE52-70] (ET7110-28)

UNIPROT #

Q92845

PROTEIN NAME

KIFAP3

SYNONYMS

FLJ22818 antibody;KAP 3 antibody;KAP-3 antibody;KAP3 antibody;KIF3AP antibody;KIFA3_HUMAN antibody;Kifap3 antibody;Kinesin associated protein 3 antibody;Kinesin-associated protein 3 antibody;SMAP antibody;Smg GDS antibody;Smg GDS associated protein antibody;Smg GDS-associated protein antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1.

SUBCELLULAR LOCATION

Cytoskeleton, cytosol, endoplasmic reticulum, golgi apparatus.

FUNCTION

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.