TRF2 Rabbit Polyclonal Antibody (ER1902-70)

UNIPROT #

Q15554

PROTEIN NAME

TRF2

SYNONYMS

Telomeric DNA binding protein antibody;Telomeric DNA-binding protein antibody;Telomeric repeat binding factor 2 antibody;Telomeric repeat binding protein 2 antibody;Telomeric repeat-binding factor 2 antibody;TERF 2 antibody;Terf2 antibody;TERF2_HUMAN antibody;TRBF 2 antibody;TRBF2 antibody;TRF 2 antibody;TRF2 antibody;TTAGGG repeat binding factor 2 antibody;TTAGGG repeat-binding factor 2 antibody

TISSUE SPECIFICITY

Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and rapidly localizes to damage sites.; Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres.

SUBCELLULAR LOCATION

Nucleus, Chromosome, telomere.

FUNCTION

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.