CTCF Recombinant Rabbit Monoclonal Antibody [JM10-61] (ET1703-90)

UNIPROT #

P49711

PROTEIN NAME

CTCF

SYNONYMS

11 zinc finger protein antibody;11 zinc finger transcriptional repressor antibody;11-zinc finger protein antibody;CCCTC binding factor (zinc finger protein) antibody;CCCTC binding factor antibody;CCCTC-binding factor antibody;Ctcf antibody;CTCF_HUMAN antibody;CTCFL paralog antibody;MRD21 antibody;Transcriptional repressor CTCF antibody

SEQUENCE SIMILARITIES

Belongs to the CTCF zinc-finger protein family.

TISSUE SPECIFICITY

Ubiquitous. Absent in primary spermatocytes.

POST-TRANSLATIONAL MODIFICATION

Sumoylated on Lys-74 and Lys-689; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2 promoter.

SUBCELLULAR LOCATION

Nucleoplasm, Chromosome, centromere.

FUNCTION

CTCF belongs to the zinc finger transcription factor family, and it recognizes unusually long and remarkably divergent DNA target sequences to influence expression of many various genes. The DNA-binding domain of CTCF is composed of 11 Zn fingers including 10 that are of C2H2 class, and 1 that is of C2HC class, and they are highly conserved between vertebrate species. CTCF functions as a repressor of the c-myc gene and as a regulator of lysozyme gene expression. In addition, CTCF associates with the essential activator domain in the promotor region of the amyloid beta-protein precursor (APP) gene to activate transcription of APP. Expression of CTCF up-regulates APP expression and thereby, enhances synapse formations between primary neurons during development. CTCF is ubiquitously expressed and localized to the nucleus. During terminal differentiation, CTCF is negatively regulated by differential phosphorylation and also by decreases in CTCF mRNA and protein expression.