DNMT3A Rabbit Polyclonal Antibody (ER1902-62)

UNIPROT #

Q9Y6K1

PROTEIN NAME

DNMT3A

SYNONYMS

DNA (cytosine 5) methyltransferase 3 alpha antibody;DNA (cytosine 5) methyltransferase 3A antibody;DNA (cytosine-5)-methyltransferase 3A antibody;DNA cytosine methyltransferase 3A2 antibody;DNA methyltransferase 3 alpha antibody;DNA methyltransferase 3a antibody;DNA methyltransferase HsaIIIA antibody;DNA MTase HsaIIIA antibody;DNM3A_HUMAN antibody;DNMT 3a antibody;DNMT antibody;Dnmt3a antibody;DNMT3A2 antibody;M.HsaIIIA antibody;MCMT antibody;OTTHUMP00000201149 antibody;TBRS antibody

SEQUENCE SIMILARITIES

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

TISSUE SPECIFICITY

Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.

POST-TRANSLATIONAL MODIFICATION

Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.

SUBCELLULAR LOCATION

Nucleus, cytoplasm.

FUNCTION

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.