RUVB2 Mouse Monoclonal Antibody [A1E12] (EM1901-58)

UNIPROT #

Q9Y230

PROTEIN NAME

RUVB2

SYNONYMS

48 kDa TATA box-binding protein-interacting protein antibody;48 kDa TBP-interacting protein antibody;48-kDa TATA box-binding protein-interacting protein antibody;48-kDa TBP-interacting protein antibody;51 kDa erythrocyte cytosolic protein antibody;CGI-46 antibody;EC=3.6.1.- antibody;ECP-51 antibody;ECP51 antibody;Erythrocyte cytosolic protein, 51-KD antibody;INO80 complex subunit J antibody;INO80J antibody;MGC144733 antibody;MGC144734 antibody;MGC52995 antibody;mp47 antibody;p47 antibody;p47 protein antibody;Repressing pontin 52 antibody;Reptin 52 antibody;REPTIN antibody;RuvB (E coli homolog)-like 2 antibody;RUVB, E. coli, homolog-like 2 antibody;RuvB-like 2 (E. coli) antibody;RuvB-like 2 antibody;RuvB-like protein 2 antibody;RUVB2 antibody;RUVB2_HUMAN antibody;RUVBL2 antibody;RVB2 antibody;TAP54-beta antibody;TATA box-binding protein-interacting protein, 48-KD antibody;TBP-interacting protein, 48-KD antibody;TIH2 antibody;TIP48 antibody;TIP49b antibody;TIP60-associated protein 54-beta antibody;wu:fi25f01 antibody;zreptin antibody

SEQUENCE SIMILARITIES

Belongs to the RuvB family.

TISSUE SPECIFICITY

Ubiquitously expressed. Highly expressed in testis and thymus.

SUBCELLULAR LOCATION

Nucleus matrix, nucleoplasm, cytoplasm, membrane.

FUNCTION

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.