TIP49A Rabbit Polyclonal Antibody (HA500355)

UNIPROT #

Q9Y265

PROTEIN NAME

TIP49A

SYNONYMS

49 kDa TATA box binding protein interacting protein antibody;49 kDa TATA box-binding protein-interacting protein antibody;49 kDa TBP interacting protein antibody;49 kDa TBP-interacting protein antibody;54 kDa erythrocyte cytosolic protein antibody;ECP-54 antibody;ECP54 antibody;ERYTHROCYTE CYTOSOLIC PROTEIN, 54-KD antibody;INO80 complex subunit H antibody;NMP 238 antibody;Nuclear matrix protein 238 antibody;Pontin 52 antibody;PONTIN antibody;RuvB like 1 antibody;RuvB like AAA ATPase 1 antibody;RuvB-like 1 antibody;RUVB1_HUMAN antibody;RUVBL1 antibody;RVB1 antibody;TAP54 alpha antibody;TAP54-alpha antibody;TIP49 antibody;TIP49a antibody;TIP60 associated protein 54 alpha antibody;TIP60-associated protein 54-alpha antibody

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton, Membrane, Nucleus.

FUNCTION

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation. May be able to bind plasminogen at cell surface and enhance plasminogen activation.