HMGA1 Recombinant Rabbit Monoclonal Antibody [JE58-17] (HA722280)

UNIPROT #

P17096

PROTEIN NAME

HMGA1

SYNONYMS

High mobility group (nonhistone chromosomal) protein isoforms I and Y antibody;High mobility group AT hook 1 antibody;High mobility group AT-hook protein 1 antibody;High mobility group protein 1 antibody;High mobility group protein A1 antibody;High mobility group protein HMG-I/HMG-Y antibody;High mobility group protein Ia antibody;High mobility group protein R antibody;HMG R antibody;HMG-I(Y) antibody;HMGA1 antibody;HMGA1_HUMAN antibody;HMGA1A antibody;HMGIY antibody;MGC12816 antibody;MGC4242 antibody;MGC4854 antibody;Nonhistone chromosomal high mobility group protein HMG I/HMG Y antibody

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene. This gene encodes a non-histone chromatin protein involved in many cellular processes, including regulation of inducible gene transcription, DNA replication, heterochromatin organization, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. HMGA1 proteins are quite small (~10-12 kDa) and basic molecules, and consist of three AT-hooks with the RGRP (Arg-Gly-Arg-Pro) core motif, a novel cross-linking domain located between the second and third AT-hook, and a C-terminal acidic tail characteristic for the HMG family comprising HMGA, HMGB and HMGN proteins.