HMGB2 Rabbit Polyclonal Antibody (ER1706-52)

UNIPROT #

P26583

PROTEIN NAME

HMGB2

SYNONYMS

C80539 antibody;High mobility group (nonhistone chromosomal) protein 2 antibody;High mobility group box 2 antibody;High mobility group protein 2 antibody;High mobility group protein B2 antibody;HMG 2 antibody;HMG B2 antibody;HMG-2 antibody;HMG2 antibody;HMGB2 antibody;HMGB2_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the HMGB family.

TISSUE SPECIFICITY

Expressed in gastric and intestinal tissues (at protein level).

POST-TRANSLATIONAL MODIFICATION

Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).; Acetylation enhances nucleosome binding and chromation remodeling activity.

SUBCELLULAR LOCATION

Secreted. Nucleus. Cytoplasm.

FUNCTION

High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.