ILF3 Recombinant Rabbit Monoclonal Antibody [JG37-63] (ET7108-49)

UNIPROT #

Q12906

PROTEIN NAME

ILF3

SYNONYMS

CBTF antibody;Double stranded RNA binding protein 76 antibody;Double-stranded RNA-binding protein 76 antibody;DRBF antibody;DRBP76 antibody;ILF3 antibody;ILF3_HUMAN antibody;Interleukin enhancer binding factor 3 antibody;Interleukin enhancer-binding factor 3 antibody;M phase phosphoprotein 4 antibody;M-phase phosphoprotein 4 antibody;MPHOSPH4 antibody;MPP4 antibody;NF AT 90 antibody;NF-AT-90 antibody;NF110 antibody;NF90 antibody;NFAR antibody;Nuclear factor associated with dsRNA antibody;Nuclear factor of activated T cells 90 kDa antibody;Nuclear factor of activated T-cells 90 kDa antibody;TCP80 antibody;Translational control protein 80 antibody

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.; Methylated by protein arginine N-methyltransferase 1.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

ILF3 (interleukin enhancer binding factor 3) or TCP80 (translational control protein 80), is a ubiquitously expressed nuclear protein that exists in a heterodimer with NF45. NF90 contains two DRBM (double-stranded RNA(dsRNA-)-binding) domains and one DZF domain and, in association with NF45 primarily participates in the regulation of IL-2 expression by binding to the antigen receptor response element (ARRE) target sequence of the IL-2 enhancer. In neuronal cells, the NF45/NF90 heterodimer can repress human rhinovirus type 2 replication by binding to a 5' untranslated region of the viral RNA that encodes the internal ribosome entry site (IRES). NF45 and NF90 belong to the double-stranded RNA-binding protein family and both are substrates for the dsRNA-activated protein kinase, PKR. Due to alternative splicing events, six isoforms exist for NF90, namely NFAR-2 (or ILF3-E), NFAR-1 (or DRBP76), isoform 3, DRBP76α (or ILF3-A), DRBP76δ (also known as DRBP76γ or ILF3-C) and isoform 6.