ARID1A Recombinant Rabbit Monoclonal Antibody [JJ09-01] (ET1701-60)

UNIPROT #

O14497

PROTEIN NAME

ARID1A

SYNONYMS

actin-dependent regulator of chromatin subfamily F member 1 antibody;ARI1A_HUMAN antibody;ARID domain containing protein 1A antibody;ARID domain-containing protein 1A antibody;ARID1A antibody;AT rich interactive domain 1A (SWI like) antibody;AT rich interactive domain 1A antibody;AT rich interactive domain containing protein 1A antibody;AT-rich interactive domain-containing protein 1A antibody;B120 antibody;BAF250 antibody;BAF250A antibody;BM029 antibody;brain protein 120 antibody;BRG1 associated factor 250 antibody;BRG1 associated factor 250a antibody;BRG1-associated factor 250 antibody;BRG1-associated factor 250a antibody;C1ORF4 antibody;chromatin remodeling factor p250 antibody;chromosome 1 open reading frame 4 antibody;ELD antibody;hELD antibody;hOSA1 antibody;matrix-associated antibody;MRD14 antibody;Osa homolog 1 antibody;OSA1 antibody;OSA1 nuclear protein antibody;P270 antibody;SMARCF1 antibody;SWI like protein antibody;SWI SNF complex protein p270 antibody;SWI-like protein antibody;SWI/SNF complex protein p270 antibody;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 antibody;SWI/SNF-related antibody

TISSUE SPECIFICITY

Highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and PBL, and at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2α) and Brg-1 (also designated SNF2β) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits, such as BAF250a (p270 or ARID 1A) and BAF250b(ARID1B), are thought to play regulatory roles.