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LXR alpha Recombinant Rabbit Monoclonal Antibody [JA20-38] (ET1704-51)

Price: Regular price $385.00

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Catalog# ET1704-51

Rabbit Monoclonal to LXR alpha

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

LXR alpha Recombinant Rabbit Monoclonal Antibody [JA20-38] (ET1704-51)

Immunogen

Synthetic peptide within human lxr alpha aa 49-98 / 447.

Host

Rabbit

Positive Control

Jurkat cell lysate, HeLa cell lysate, mouse stomach tissue lysate, mouse lung tissue lysate, rat liver tissue lysate, rat lung tissue lysate, HepG2, human placenta tissue, mouse testis tissue, human spleen tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JA20-38

RRID

AB_3070498

APPLICATION DILUTION

  • WB

  • 1:5,000

  • IF-Cell

  • 1:50-1:100

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 50 kDa

Isotype

IgG

TARGET

UNIPROT #

Q13133

PROTEIN NAME

LXR alpha

SYNONYMS

Liver X receptor alpha antibody;LXR a antibody;LXRA antibody;NR1H3 antibody;NR1H3_HUMAN antibody;Nuclear receptor subfamily 1 group H member 3 antibody;Oxysterols receptor LXR alpha antibody;Oxysterols receptor LXR-alpha antibody;RLD 1 antibody;RLD1 antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR1 subfamily.

TISSUE SPECIFICITY

Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated leading to its degradation by the proteasome.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

CITATIONS

  • Gao Yinhuang,et al

    Buqi Huoxue Tongnao prescription protects against chronic cerebral hypoperfusion via regulating PI3K/AKT and LXRα/CYP7A1 signaling pathways

  • Wang, M. S., Han, Q. S., Jia, Z. R., Chen, C. S., Qiao, C., Liu, Q. Q., Zhang, Y. M., Wang, K. W., Wang, J., Xiao, K., & Ding, X. S.

    PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway. Acta pharmacologica Sinica, 10.1038/s41401-021-00638-z. Advance online publication.

  • Mi-Zhuan Li ,et al

    Novel Guanidinium-Functionalized Stigmasterol for Bile Salt Binding and Serum Cholesterol Reduction: Synthesis, Interaction Mechanisms, and In Vivo Function

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