PIAS1 Recombinant Rabbit Monoclonal Antibody [JE36-84] (HA720076)

UNIPROT #

O75925

PROTEIN NAME

PIAS1

SYNONYMS

AR interacting protein antibody;DDXBP1 antibody;DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 antibody;DEAD/H box binding protein 1 antibody;DEAD/H box-binding protein 1 antibody;E3 SUMO-protein ligase PIAS1 antibody;GBP antibody;Gu binding protein antibody;Gu-binding protein antibody;GU/RH-II antibody;Pias1 antibody;PIAS1_HUMAN antibody;Protein inhibitor of activated STAT protein 1 antibody;Protein inhibitor of activated STAT, 1 antibody;RNA helicase II binding protein antibody;RNA helicase II-binding protein antibody;Zinc finger, MIZ-type containing 3 antibody;ZMIZ3 antibody

SUBCELLULAR LOCATION

Nucleus speckle, PML body.

FUNCTION

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB.