Retinoid X Receptor alpha Recombinant Rabbit Monoclonal Antibody [JG99-38] (ET7108-99)

UNIPROT #

P19793

PROTEIN NAME

Retinoid X Receptor alpha

SYNONYMS

FLJ00280 antibody;FLJ00318 antibody;FLJ16020 antibody;FLJ16733 antibody;MGC102720 antibody;NR2B1 antibody;Nuclear receptor subfamily 2 group B member 1 antibody;OTTHUMP00000022510 antibody;Retinoic acid receptor RXR alpha antibody;Retinoic acid receptor RXR-alpha antibody;Retinoid X nuclear receptor alpha antibody;Retinoid X receptor alpha antibody;RXR alpha1 antibody;Rxra antibody;RXRA_HUMAN antibody;RXRalpha1 antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR2 subfamily.

TISSUE SPECIFICITY

Expressed in lung fibroblasts (at protein level). Expressed in monocytes. Highly expressed in liver, also found in kidney and brain.

POST-TRANSLATIONAL MODIFICATION

Acetylated by EP300; acetylation enhances DNA binding and transcriptional activity.; Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain (By similarity). Constitutively phosphorylated on Ser-21 in the presence or absence of ligand (By similarity). Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260 (By similarity). Phosphorylated on Ser-27, in vitro, by PKA. This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA.; Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6.

SUBCELLULAR LOCATION

Mitochondrion, Nucleus, Cytoplasm.

FUNCTION

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.