Phospho-c-Jun (S63) Recombinant Rabbit Monoclonal Antibody [SY0297] (ET1608-4)

UNIPROT #

P05412

PROTEIN NAME

Phospho-c-Jun (S63)

SYNONYMS

Activator protein 1 antibody;AP 1 antibody;AP1 antibody;cJun antibody;Enhancer Binding Protein AP1 antibody;Jun Activation Domain Binding Protein antibody;JUN antibody;Jun oncogene antibody;JUN protein antibody;Jun proto oncogene antibody;JUN_HUMAN antibody;JUNC antibody;Oncogene JUN antibody;p39 antibody;Proto oncogene c jun antibody;Proto oncogene cJun antibody;Proto-oncogene c-jun antibody;Transcription Factor AP 1 antibody;Transcription factor AP-1 antibody;Transcription Factor AP1 antibody;V jun avian sarcoma virus 17 oncogene homolog antibody;V jun sarcoma virus 17 oncogene homolog (avian) antibody;V jun sarcoma virus 17 oncogene homolog antibody;V-jun avian sarcoma virus 17 oncogene homolog antibody;vJun Avian Sarcoma Virus 17 Oncogene Homolog antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family. Jun subfamily.

TISSUE SPECIFICITY

Expressed in the developing and adult prostate and prostate cancer cells.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7.; Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.; Acetylated at Lys-271 by EP300.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

c-Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor discovered. The proto-oncogene c-Jun is the cellular homolog of the viral oncoprotein v-jun (P05411). The viral homolog v-jun was discovered in avian sarcoma virus 17 and was named for ju-nana, the Japanese word for 17. The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.