PIAS4 Rabbit Polyclonal Antibody (HA500411)

UNIPROT #

Q8N2W9

PROTEIN NAME

PIAS4

SYNONYMS

E3 SUMO protein ligase PIAS4 antibody;E3 SUMO-protein ligase PIAS4 antibody;FLJ12419 antibody;MGC35296 antibody;PAIASgamma antibody;PIAS 4 antibody;PIAS gamma antibody;PIAS-gamma antibody;Pias4 antibody;PIAS4_HUMAN antibody;PIASG antibody;PIASgamma antibody;PIASy antibody;Protein inhibitor of activated STAT 4 antibody;Protein inhibitor of activated STAT protein 4 antibody;Protein inhibitor of activated STAT protein gamma antibody;Protein inhibitor of activated STAT protein PIASy antibody;Zinc finger MIZ type containing 6 antibody;ZMIZ 6 antibody;ZMIZ6 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes.