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STAT4 Recombinant Rabbit Monoclonal Antibody [JJ08-85] (ET1701-42)

Price: Regular price $385.00

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Catalog# ET1701-42

Rabbit Monoclonal to STAT4

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

STAT4 Recombinant Rabbit Monoclonal Antibody [JJ08-85] (ET1701-42)

Immunogen

Synthetic peptide within human stat4 aa 700-748.

Host

Rabbit

Positive Control

SiHa cell lysate, A549 cell lysate, HeLa cell lysate, MCF7 cell lysate, SW480 cell lysate, HeLa, human colon carcinoma tissue, human tonsils tissue, mouse testis tissue, rat testis tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JJ08-85

RRID

AB_3070210

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:100-1:500

  • IF-Tissue

  • 1:100-1:500

  • IHC-P

  • 1:50-1:1,000

  • FC

  • 1:1,000

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 86 kDa

Isotype

IgG

TARGET

UNIPROT #

Q14765

PROTEIN NAME

STAT4

SYNONYMS

Signal transducer and activator of transcription 4 antibody;SLEB11 antibody;STAT4 antibody;STAT4_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the transcription factor STAT family.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

CITATIONS

  • Jiang, M., Liu, J., Liu, W., Zhu, X., Bano, Y., Liao, H., Li, H., & Jiang, H. H.

    Bone marrow stem cells secretome accelerates simulated birth trauma-induced stress urinary incontinence recovery in rats. Aging, 13(7), 10517–10534.

  • Wang, Y., Wu, M., Chen, D., Tan, B., Lin, P., Huang, D., & Ye, C.

    SDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4

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