STAT6 Recombinant Rabbit Monoclonal Antibody [SY13-09] (ET1605-49)

UNIPROT #

P42226

PROTEIN NAME

STAT6

SYNONYMS

12S1644 antibody;D12S1644 antibody;IL 4 STAT antibody;IL-4 Stat antibody;IL4 STAT antibody;Interleukin 4 Induced antibody;Interleukin 4 Induced Transcription Factor IL4 STAT antibody;Signal transducer and activator of transcription 6 antibody;Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody;Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody;Signal transducer and activator of transcription 6, interleukin 4 induced antibody;STAT 6 antibody;STAT interleukin4 induced antibody;STAT, interleukin4 induced antibody;Stat6 antibody;STAT6_HUMAN antibody;STAT6B antibody;STAT6C antibody;Transcription factor IL 4 STAT antibody

SEQUENCE SIMILARITIES

Belongs to the transcription factor STAT family.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.; Mono-ADP-ribosylated by PARP14.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of proteins that have been designated Stats (signal transducers and activators of transcription). The first members of this family to be described include Stat1α p91, Stat1β p84 (a form of p91 that lacks 38 COOH-terminal amino acids) and Stat2 p113. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Stat3, which becomes activated in response to epidermal growth factor (EGF) and interleukin-6 (IL-6), but not interferon-γ (IFN-γ) or Stat4, is an additional member of this family. It has been suggested that the phosphorylated forms of both Stat3 and Stat4 form homodimers as well as heterodimers with the other members of the Stat family, and that differential activation of different Stat proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Other members of the Stat family include Stat5, which has been shown to be activated by prolactin and by IL-3, and Stat6 (also designated IL-4 Stat), which is involved in IL-4-activated signaling pathways.