Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38] (HA722452)

UNIPROT #

Q96Q15

PROTEIN NAME

Smg1

SYNONYMS

61E3.4 antibody;ATX antibody;hSMG-1 antibody;hSMG1 antibody;KIAA0421 antibody;Lambda interacting protein antibody;Lambda-interacting protein antibody;Lambda/iota protein kinase C interacting protein antibody;Lambda/iota protein kinase C-interacting protein antibody;LIP antibody;Phosphatidylinositol 3 kinase related kinase antibody;Phosphatidylinositol 3 kinase related protein kinase antibody;PI 3 kinase related kinase SMG 1 antibody;Serine/threonine protein kinase SMG1 antibody;Serine/threonine-protein kinase SMG1 antibody;SMG-1 antibody;smg1 antibody;SMG1_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.